| Autor: |
TX TEOH, JAUHARATUNNUR ISHAK, SM LIM, CHAW SH, CAROLYN CW YIM |
| Předmět: |
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| Zdroj: |
Medicine & Health (Universiti Kebangsaan Malaysia); 2021 Supplement, Vol. 16, p31-31, 1p |
| Abstrakt: |
Objective: Caesarean section under subarachnoid block (SAB) is often associated with shivering. Although shivering may have beneficial thermoregulatory effect, perioperative shivering is an unfavourable event as it places the body under increased physiological stress. Ondansetron, a 5-HT3 antagonist is a commonly used antiemetic during pregnancy and perioperatively to treat post-operative nausea and vomiting (PONV). Previous studies showed promising results on reducing post-spinal shivering. The objective of this study is to establish the efficacy of IV Ondansetron 4 mg in reducing the incidence of post-spinal shivering in our local population. Methods: In this double-blind study, 120 patients of MRCOG grade 2-4 LSCS under subarachnoid block (SAB) were recruited and randomised equally into Group O (received IV Ondansetron 4 mg/2mls) and Group P (received IV NaCl 0.9% 2 mls) before SAB. Shivering assessment were performed immediately after SAB and every 30 minutes and severity graded on scale of 0-4, 4 being generalized vigorous shivering. Patients with shivering grade 3-4 was treated with IV pethidine and total dose required documented. Body temperature trend throughout the duration in the operation theatre (OT) was recorded while the OT temperature maintained constant at a range of 16-22°C. Incidence of PONV throughout operation and postoperatively was also documented. Results: Group O has a statistically significant lower incidence of post-spinal shivering compared to Group P (16, 26.7% vs 30, 50%; P=0.009). Group O required less IV pethidine for shivering treatment. Group O also reported a statistically significant lower incidence of PONV compared to Group P. The body temperature trend throughout the duration in OT does not show statistical difference between Group O and Group P at various time point. Conclusion: IV Ondansetron 4 mg is effective in preventing post-spinal shivering in parturient and reduces the need of IV pethidine to treat post-spinal shivering. IV Ondansetron 4mg is also effective in preventing PONV for parturient. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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