| Autor: |
Breathnach, S. M., Wells, G. C., Valdimarsson, H. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; May1981, Vol. 104 Issue 5, p567-573, 7p |
| Abstrakt: |
A 58-year-old man with chronic ‘idiopathic’ pyoderma gangrenosum, recurrent secondary staphylococcal infection, nail candidiasis, markedly impaired lymphocyte function and a serum blocking factor is described. Despite an initially favourable response to immunosuppressive therapy, the patient later relapsed whilst on high dose systemic corticostcroids and azathioprine. Immune function remains abnormal 3 years after cessation of azathioprine. Attempted immunostimulation with Corynebacterium parvum proved unsuccessful. A striking but transient increase in lymphocyte function followed parenteral iron therapy for an unexplained iron-deficiency anaemia. Gradual reduction in prednisone dosage to 5 mg daily has coincided with a period of clinical resolution and modest improvement in lymphocyte reactivity. Prolonged immunosuppressive therapy may be inadvisable in chronic idiopathic pyoderma gangrenosum associated with defective cellular immunity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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