Maternal LINE-1 DNA Methylation in Early Spontaneous Preterm Birth.
| Autor: | Barišić, Anita, Stanković, Aleksandra, Stojković, Ljiljana, Pereza, Nina, Ostojić, Saša, Peterlin, Ana, Peterlin, Borut, Vraneković, Jadranka |
|---|---|
| Předmět: |
KRUSKAL-Wallis Test
PREMATURE infants ANALYSIS of variance DISEASES CASE-control method GESTATIONAL age REGRESSION analysis MANN Whitney U Test DNA methylation LYMPHOCYTES CHILD health services DESCRIPTIVE statistics TRANSFERASES STATISTICAL hypothesis testing RESEARCH funding INFANT mortality POLYMERASE chain reaction DATA analysis software |
| Zdroj: | Biological Research for Nursing; Jan2022, Vol. 24 Issue 1, p85-93, 9p |
| Abstrakt: | Despite considerable effort aimed at decreasing the incidence of spontaneous preterm birth (SPTB), it remains the leading cause of infant mortality and morbidity. The aim of this study was to evaluate maternal LINE-1 DNA methylation (DNAm), along with DNMT polymorphisms and factors proposed to modulate DNAm, in patients who delivered early preterm. This case-control study included women who delivered spontaneously early preterm (23–336/7 weeks of gestation), and control women. DNAm was analyzed in peripheral blood lymphocytes by quantification of LINE-1 DNAm using the MethyLight method. There was no significant difference in LINE-1 DNAm between patients with early PTB and controls. Among the investigated predictors, only the history of previous PTB was significantly associated with LINE-1 DNAm in PTB patients (β = −0.407; R2 = 0.131; p = 0.011). The regression analysis showed the effect of DNMT3B rs1569686 TT+TG genotypes on LINE-1 DNAm in patients with familial PTB (β = −0.524; R2 = 0.275; p = 0.037). Our findings suggest novel associations of maternal LINE-1 DNA hypomethylation with DNMT3B rs1569686 T allele. These results also contribute to the understanding of a complex (epi)genetic and environmental relationship underlying the early PTB. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
| Externí odkaz: |
|