| Autor: |
Erdenetsogt, Uugangerel, Nadmid, Suvd, Paulus, Constanze, Chanagsuren, Ganchimeg, Dolgor, Erdenechimeg, Gotov, Choijamts, Dahse, Hans-Martin, Luzhetskyy, Andriy, Dagvadorj, Enkhmaa |
| Předmět: |
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| Zdroj: |
Natural Product Research; Dec 2021, Vol. 35 Issue 24, p5960-5963, 4p |
| Abstrakt: |
Pyrethrum pulchrum Ledeb. has been a phytochemically unexplored Mongolian medicinal folklore plant. In this study, its total flavonoid content was determined and fourteen flavonoids (1-14) were isolated from the aerial parts of P. pulchrum. Their structures were elucidated on the basis of spectroscopic data. The compounds 12-14, methoxyflavones, were tested for antiproliferative and cytotoxic activity against A549, HeLa, K-562, THP-1 and HUVEC cell lines. This is the first report on the effects of 5,7,4'-trihydroxy-3,6,3'-trimethoxyflavone (13) against all tested cell lines and it exhibited potent activity against chronic myeloid leukemia K-562 and acute monocytic leukemia THP-1 cells, each with GI50 value at 2.0 μg/mL. The 5,4'-dihydroxy-3,6,7,3'-tetramethoxyflavone (14) showed the most potent activity against THP-1 (GI50 = 1.1 μg/mL) and the highest cytotoxicity (5.6 μg/mL). In addition, acute toxicity of plant ethanol extract was evaluated and the lethal dose (LD50) was estimated at 1048 mg/kg. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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