Productive infection of the bone marrow cells in feline immunodeficiency virus infected cats.

Autor:	Sandy, J. R., Robinson, W. F., Bredhauer, B., Kyaw-Tanner, M., Howlett, C. R.
Předmět:	FELINE immunodeficiency virus FELINE immunodeficiency virus infection BONE marrow VIRUS diseases LENTIVIRUS diseases VETERINARY virology CAT diseases
Zdroj:	Archives of Virology; May2002, Vol. 147 Issue 5, p1053-1059, 7p
Abstrakt:	Summary. Bone marrow stromal cells (BMSC) from cats experimentally infected with feline immunodeficiency virus (FIV) were shown to contain FIV provirus using polymerase chain reaction and viral products were detected in culture supernatant using reverse transcriptase and enzyme linked immunosorbent assay techniques. Peripheral blood mononuclear cells from FIV-free cats co-cultured with infected bone marrow cells became productively infected with FIV. Such evidence supports the hypothesis that BMSC are a reservoir for FIV. Furthermore, BMSC produced virions capable of infecting susceptible cells and may represent an important source of infectious virus to cells of the macrophage lineage and/or hemopoietic progenitor cells, both of which ultimately become widely disseminated throughout the body. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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