| Autor: |
Timonen, P., Friend, D., Abeywickrama, K., Laburte, C., von Graffenried, B., Feutren, G. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; Jun1990 Supplement 36, Vol. 122, p33-39, 7p |
| Abstrakt: |
The efficacy of cyclosporin A (CyA) in severe psoriasis was analysed in 457 adult patients included in five European multicentre dose-finding studies. Initial CyA doses were 1·25 mg/kg/day in 33 patients, 2·5–3 mg/kg/day in 285 and 5 mg/kg/day in 139. After 3 months of treatment, the reduction of the Psoriasis Area and Severity Index (PASI) score was 35 ± 6% with 1·25 mg/kg/day of CyA, 57 ± 2% with 2.5 mg or 3 mg/kg/day and 86 ± 2% with 5 mg/kg/day (P < 0.001). The rates of success, defined by a PASI score reduction ≥75% or a score ≤ 8, were 24%, 52%, and 88%, respectively. There were no differences in age, initial severity or duration of psoriasis. The improvement was maintained for 9 months or more in the majority of patients receiving continuous CyA therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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