| Autor: |
Nguyen, Thi Xuan Thu, Dang, Duc Long, Ngo, Van Quang, Trinh, Tat Cuong, Trinh, Quang Nam, Do, Trung Dong, Thanh, Thi Thu Thuy |
| Předmět: |
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| Zdroj: |
Natural Product Research; Dec 2021, Vol. 35 Issue 23, p5160-5165, 6p |
| Abstrakt: |
In this study, a new stigmastane, vernonioside V, was isolated from the ethanol extract of leaves of Vernonia amygdalina along with a known flavonoid, cynaroside, and then anti-inflammatory activity of isolated compounds was investigated. The result showed that vernonioside V at concentration of 30 µg/mL strongly inhibited TNFα, IL-6, and IL-8 inflammatory cytokine production. Furthermore, LPS-induced supreoxide generation in Raw 264.7 were significantly reduced by pre-treatment of vernonioside V (30 µg/mL). These data indicated that vernonioside V had inhibitory activities on pro-inflammatory cytokine in LPS-stimulated Raw 264.7 through reactive oxygen species (ROS). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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