Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction.

Autor:	Chen, Yang, Ding, Congcong, Hu, Longlong, Ruan, Yuehua, Zou, Kai, Dai, Cong, Liao, Yanhui, Liao, Hanhui, Xia, Yi, Zhao, Yuanbin, Yang, Renqiang
Předmět:	MYOCARDIAL infarction LDL cholesterol URIC acid LOGISTIC regression analysis CHINESE people MYOCARDIAL infarction diagnosis HYPERURICEMIA RESEARCH TIME RESEARCH methodology PROGNOSIS RETROSPECTIVE studies EVALUATION research HYPERLIPIDEMIA RISK assessment COMPARATIVE studies HOSPITAL care LONGITUDINAL method
Zdroj:	BMC Cardiovascular Disorders; 11/30/2021, Vol. 21 Issue 1, p1-9, 9p
Abstrakt:	Background: Data on the relationship of baseline serum uric acid (SUA) with development of low-density lipoprotein cholesterol (LDL-C) level in patients with first acute myocardial infarction (AMI) are limited. The present study is to evaluate whether elevated SUA predicts the development of LDL-C in the first AMI.Methods: This is a retrospective 6-month cohort study of 475 hospitalized Chinese patients who underwent first AMI between January 2015 and December 2019 and were reevaluated half a year later at the Department of Cardiology, the Second Affiliated Hospital of Nanchang University, Jiangxi Province, China. The associations of baseline SUA with the percentage decrease of LDL-C (%) and LDL-C control were analyzed by using logistic regression analyses, multivariate linear regression analyses and the restricted cubic spline.Results: Over the 6-month follow-up, baseline SUA was independently and positively associated with the percentage decrease of LDL-C (%) and LDL-C control in a dose response fashion. After multivariable adjustment, per SD increment of baseline SUA (120.58 μmol/L) was associated with 3.96% higher percentage decrease of LDL-C(%). The adjusted OR (95% CI) for LDL-C control was 5.62 (2.05, 15.36) when comparing the highest tertile (SUA ≥ 437.0 μmol/L) to the lowest tertile (< 341.7 μmol/L) of baseline SUA.Conclusions: Among Chinese patients with first AMI, higher baseline SUA was associated with higher LDL-C deduction percentage (%), and higher rate of LDL-C control in the short-term follow-up, respectively. SUA acquired when AMI occurred was prone to be profitable in predicting the risk stratification of uncontrolled LDL-C and dyslipidemia management. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink