miRNA regulation of G protein-coupled receptor mediated angiogenic pathways in cancer.

Autor: Mandal, Samanwita, Chakrabarty, Deblina, Bhattacharya, Arijit, Paul, Joydeep, Haldar, Srijan, Pal, Kuntal
Zdroj: Nucleus (0029568X); Dec2021, Vol. 64 Issue 3, p303-315, 13p
Abstrakt: Angiogenesis is an important biological process associated with plethora of physiological and patho-physiological conditions. Recent data suggests that fine balance between anti-angiogenic microRNA (miRNA) and pro-angiogenicmiRNA drive the process of neovascularization. Many of these miRNAs act via G-protein coupled receptor (GPCR) which regulates diverse physiological processes including angiogenesis. Aberrant GPCR expression and signaling through G-protein often results into uncontrolled angiogenesis, tumor development and metastasis. In this review, we discuss the new emerging insights of GPCR-miRNA network and their interaction in angiogenic pathways leading to the cancer progression. Alongside we have focused on the GPCR mediated angiogenic processes which are controlled by anti-angiogenicmiRNAs and the influence of deregulation of these miRNAs on cancer angiogenesis. Through an extensive literature survey, we identified 7 distinct miRNAs, which are playing important role in regulating angiogenesis. Through network analysis with predicted targets for reported miRNAs and pathway enrichment, 25 major cell signaling pathways associated with tumor-angiogenesis could be identified, further reinforcing the relevance of the miRNAs in the process. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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