| Autor: |
Yamina, Benaissa, Samia, Addou, Wafaa, Dib, Hafsia, Abbas, Mama, Berouis, Djamel, Saidi, Omar, Kheroua |
| Předmět: |
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| Zdroj: |
South Asian Journal of Experimental Biology; 2021, Vol. 11 Issue 4, p400-406, 7p |
| Abstrakt: |
In epidemiological studies, cow's milk protein allergy (CMPA) is the most prevalent allergy for infants or young children. This study was conducted to compare the effect of Soummam and Saifi fermented milks on mice sensitized to whey protein (ß -Lactoglobulin and a -Lactalbumin). During 28 days, the animals from the first and second lot received via an oral way the fermented milks. In a second period of time, mice from the first, second lots were sensitized via intraperitoneal way using ß-Lg, mice from third and fourth lot were sensitized by a-Lactalbumin. The antigenecity was determined by enzyme-linked immunosorbent assay (ELISA). Symptom scores were determined after in vivo challenge with ß-Lg or a-Lac. Intestinal damage was evaluated by histological analysis. Analysis of the data revealed that the titers of anti-a-lactalbumin and anti-ß-lactoglbulin IgG increased significantly in the positive control groups given Soummam and Saifi fermented milk (p <0.001). Moreover, in fermented milk-treated mice, significant clinical symptoms were observed. Analysis of histological sections revealed that fermented milk doesn't reduce the microscopic lesions induced by ß-Lg or a-Lac sensitzation. This study indicated that the administration of Soummam fermented milk can modulate effectively the immune response and protect the intestinal epithelium integrity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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