| Autor: |
Holgate, S. T., Davies, D. E., Rorke, S., Cakebread, J., Murphy, G., Powell, R. M., Holloway, J. W. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Allergy Reviews; Dec2004 Supplement 2, Vol. 4, p49-55, 7p |
| Abstrakt: |
Asthma is a disorder of the conducting airways in which Th-2 mediated inflammation interacts with structural changes to cause variable airflow obstruction. Fundamental to disordered function is the concept of bronchial hyperresponsiveness (BHR), in which the airways construct too much and too easily. It has been stated that BHR represents the‘Holy Grail’ of asthma, yet our understanding of its underlying causes(s) is poorly developed[]. Measurement of BHR has found clinical utility as a diagnostic test to help differentiate asthma from other lung disorders, but unfortunately its specificity is low. However, it is the severity of BHR and its relative independence from measures of baseline airway calibre that differentiates BHR encountered in asthma from that of other diseases such as chronic obstructive pulmonary disease (COPD), sarcoidosis and heart failure. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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