| Autor: |
Karimi-Zarchi, Mojgan, Zanbagh, Leila, Javaheri, Atiyeh, Tabatabaei, Razieh Sadat, Abbasi, Hajar, Meibodi, Bahare, Hadadan, Amaneh, Bahrami, Reza, Mirjalili, Seyed Reza, Neamatzadeh, Hossein |
| Předmět: |
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| Zdroj: |
Fetal & Pediatric Pathology; Dec 2021, Vol. 40 Issue 6, p605-611, 7p |
| Abstrakt: |
Background Insulin-like growth factor-II (IGF-II) has a prominent role in fetal growth and development. The aim of this study was to investigate the association of IGF-II Apa1 and MspI polymorphisms with intrauterine growth restriction (IUGR) risk. Methods: A total of 45 infants with IUGR and 45 infants appropriate for gestational (AGA) were enrolled. Genotyping of Apa1 and MspI polymorphisms was assayed by PCR-RFLP approach. Results: The heterozygote genotype (AG) of IGF-II Apa1 CT was associated with an increased risk of IUGR. Genotypes and alleles of IGF-II MspI polymorphism had no significant association with IUGR susceptibility (P > 0.05). Conclusions: The current study suggests that IGF-II Apa1 polymorphism is associated with an increased risk of IUGR, while IGF-II MspI showed no association with IUGR. Thus, IGF-II Apa1 polymorphism could be used as a relevant molecular marker to identify the fetus at risk of developing IUGR. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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