Phenolic profile by HPLC-ESI-MS/MS and enzymatic inhibitory effect of Bryophyllum delagoense.

Autor: Katrucha, Edenize Maria, Lopes, Jéssica, Paim, Milena, dos Santos, Júlia Candiani, Siebert, Diogo Alexandre, Micke, Gustavo Amadeu, Vitali, Luciano, Alberton, Michele Debiasi, Tenfen, Adrielli
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Zdroj: Natural Product Research; Nov 2021, Vol. 35 Issue 22, p4824-4827, 4p
Abstrakt: Bryophyllum delagoense (Eckl. & Zeyh.) Druce, native to Madagascar, is popularly known as "abyssian cactus" and popularly used in folk medicine as an analgesic and healing agent. The study methodology was divided into the phytochemical study: fractionation and identification of phenolic compounds by HLPC-ESI-MS/MS from the methanolic extract (ME), and fractions (DCMF and EAF) of leaves of B. delagoense, and biological activity with acetylcholinesterase and α-glucosidase inhibition of extracts and fractions by in vitro enzymatic techniques. Twenty-seven phenolic compounds were identified, being the highest concentration of syringic acid (87.848 mg g−1). The DCMF fraction showed the best biological activity for inhibition of α-glucosidase enzyme (0.125 mg mL−1). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index