| Autor: |
Foggin, S., Dajas-Bailador, F., Layfield, R., Jirström, E., Matveeva, A., Matallanas, D., Garcia-Munoz, A., Wynne, K., Prehn, J., Prtenjaca, N., Rob, M., Peradinovic, J., Buratti, E., Munitic, I., Deshaies, J., Triassi, V., Gagné, M., Ghosh, A., Labrecque, M., Tétreault, M. |
| Předmět: |
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| Zdroj: |
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration; 2021, Vol. 22, p58-72, 15p |
| Abstrakt: |
An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress. Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction. An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress. Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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