Insulin stimulates β-alanine uptake in skeletal muscle cells in vitro.

Autor: Santos, Lívia, Gonçalves, L. S., Bagheri-Hanei, Shirin, Möller, Gabriella Berwig, Sale, Craig, James, Ruth M., Artioli, Guilherme Giannini
Předmět:
Zdroj: Amino Acids; Nov2021, Vol. 53 Issue 11, p1763-1766, 4p
Abstrakt: We evaluated whether insulin could stimulate β-alanine uptake by skeletal muscle cells in vitro. Mouse myoblasts (C2C12) (n = 3 wells per condition) were cultured with β-alanine (350 or 700 µmol·L−1), with insulin (100 µU·mL−1) either added to the media or not. Insulin stimulated the β-alanine uptake at the lower (350 µmol·L−1) but not higher (700 µmol·L−1) β-alanine concentration in culture medium, indicating that transporter saturation might blunt the stimulatory effects of insulin. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index