| Autor: |
Lee, Hyejin, Jarhad, Dnyandev B., Lee, Ahrim, Lee, Choongho, Jeong, Lak Shin |
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| Zdroj: |
Asian Journal of Organic Chemistry; Nov2021, Vol. 10 Issue 11, p2993-2999, 7p |
| Abstrakt: |
Intrigued by the biological activity of 2′‐C‐methylribofuranosyl nucleosides, and ribavirin/acadesine, based on the bioisosteric rationale between oxygen and selenium, we herein report a design and synthesis of the 2′‐C‐methyl‐4′‐seleno‐ribavirin and ‐acadesine as potential anti‐HCV agents. The 2′‐C‐methyl 4′‐selenoribavirin was synthesized in a regio‐ and stereoselective manner and completely characterized through 2D NMR and X‐ray crystallography. While the 2′‐C‐methyl 4′‐selenoacadesine has been efficiently synthesized by utilizing purine‐ring opening/degradation procedure via nucleophilic cleavage of N3−C2 bond of a purine by ethylenediamine (EDA) as the key step. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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