Role of 18 F-FDG PET/CT in Erdheim–Chester Disease in the Era of Multimodality Imaging.

Autor:	Jois, Bhargavi, Ananthasivan, Rupa, Rawat, Parameswaran R. V. Sudarshan, Rakshit, Susmita
Předmět:	ERDHEIM-Chester disease BIOPSY MAGNETIC resonance imaging EYE-sockets LYMPHOCYTES GENE expression SEVERITY of illness index RADIOPHARMACEUTICALS OPTIC nerve DEOXY sugars COMPUTED tomography EVALUATION
Zdroj:	Indian Journal of Radiology & Imaging; Jul2021, Vol. 31 Issue 3, p729-734, 6p
Abstrakt:	Erdheim–Chester disease is a rare disease with systemic non-Langerhans cell histiocytosis, the diagnosis of which with conventional imaging modalities is challenging. We describe a case of a 73-year-old woman who was referred with a progressive history of bilateral proptosis. The magnetic resonance imaging (MRI) orbit demonstrated bilateral orbital masses with optic nerve encasement. A subsequent 18F-FDG PET/CT scan showed multi-organ disease with involvement of the orbits, pericardium, aorta, pararenal fascia, and appendicular bones. Metabolically active, easily accessible areas were selected for CT-guided biopsy. The biopsy showed sheets of foamy histiocytes with the expression of CD 68 and CD 163 consistent with a diagnosis of Erdheim–Chester disease. The FDG PET/CT played a pivotal role in establishing the diagnosis with the assessment of disease extent and further guided in the targeted biopsy. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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