| Autor: |
Puckett, Lauren M., Rajkotia, Poonam, Coppola, Lisa, Baumgartner, Lori, Roberts, Amity L., Maldonado, Yanice, Girotto, Jennifer E. |
| Předmět: |
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| Zdroj: |
Journal of Pediatric Pharmacology & Therapeutics; 2021, Vol. 26 Issue 8, p802-808, 7p |
| Abstrakt: |
OBJECTIVE Identification of organisms directly from positive blood culture by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has the potential for improved clinical outcomes through earlier organism identification and shorter time to appropriate clinical intervention. The uses of this technology in pediatric patients and its impact in this patient population have not been well described. METHODS Direct from positive blood culture organism identification via MALDI-TOF was implemented in September 2019. A quality improvement project was performed to assess its impact on admissions for contaminant blood cultures and time to effective and optimal antimicrobials and clinical decision-making. A pre- and post-implementation retrospective review for consecutive September through February time periods, was conducted on patients with positive monomicrobial blood cultures. Statistics were evaluated using Mann-Whitney U and X2 tests. RESULTS One hundred nineteen patients with 131 unique blood cultures (65 in pre- and 66 in postimplementation) were identified. Time to identification was shorter, median 35.4 hours (IQR, 22.7-54.3) versus 42.3 hours (IQR, 36.5-49) in post- and pre-groups, respectively (p = 0.02). Patients were less likely to be admitted for a contaminated blood culture in the post-implementation, 26% versus 11% in the preimplementation (p = 0.03) group. In patients treated for bacteremia, there was a shorter time to optimal therapy from Gram stain reporting in the post-implementation (median 42.7 hours [IQR, 27.2-72]) versus preimplementation (median 60.8 hours [IQR, 42.9-80.6]) (p = 0.03). CONCLUSIONS Direct from positive blood culture identification by MALDI-TOF decreased time to effective and optimal antimicrobials and decreased unnecessary admission in pediatric patients for contaminated blood cultures. ABBREVIATIONS ASP, antimicrobial stewardship program; MALDI-TOF MS, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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