| Autor: |
Maksimchuk, P O, Hubenko, K O, Seminko, V V, Karbivskii, V L, Tkachenko, A S, Onishchenko, A I, Prokopyuk, V Yu, Yefimova, S L |
| Předmět: |
|
| Zdroj: |
Nanotechnology; 1/29/2022, Vol. 33 Issue 5, p1-10, 10p |
| Abstrakt: |
Oxidative stress caused by an overproduction of reactive oxygen species (ROS) is the key factor in developing a variety of pathological conditions. Recently various nanomaterials have attracted growing interest as nanoantioxidants with ROS-regulating ability. Here, for the first time, we report on high antioxidant behavior (enzyme-like activity) of GdYVO4:Eu3+ nanoparticles (GdYVO NPs) revealed by spectroscopic methods both in cell-free and biological milieu using various ROS sensors. It was revealed that GdYVO NPs (d = 2 nm) effectively scavenge hydroxyl radicals · O H , superoxide anions O 2 · â' , hydrogen peroxide H 2 O 2 , peroxyl radicals R O O · , and remarkably reduce the lipopolysaccharide-induced ROS generation in rat leukocytes. The antioxidant activity of GdYVO NPs is ascribed to high amount of V4+ and V3+ ions in the structure of the NPs and the reversible switching V 3 + â†" V 4 + and V 4 + â†" V 5 + vanadium oxidation states. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
