The AP-1 family of transcription factors are important regulators of gene expression within Leydig cells.

Autor: Nguyen, Ha Tuyen, Najih, Mustapha, Martin, Luc J.
Zdroj: Endocrine (1355008X); Dec2021, Vol. 74 Issue 3, p498-507, 10p
Abstrakt: Purpose: Members of the AP-1 family of transcription factors are immediate early genes being modulated by different extracellular signals. The aim of this review is to highlight the important roles of AP-1 members in transcriptional regulation of genes important for testicular Leydig cell function and male testosterone production. Methods: A search of the relevant literature was performed in Google Scholar and NCBI Pubmed for AP-1 members and Leydig cells. Additional information was accessed from references of relevant articles. Only primary data from original peer-reviewed articles was considered for this review. Results: Different signaling pathways important for Leydig cells' functions are involved in the regulation of the activity of AP-1 members. These transcription factors participate in the regulation of genes related to different biological processes important for Leydig cells. Conclusions: We conclude that members of the AP-1 family of transcription factors play critical roles in the regulation of Leydig cell proliferation, steroidogenesis, and cell-to-cell communication. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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