| Autor: |
Levina, V. I., Trukhacheva, L. A., Pyatakova, N. V., Arzamastsev, A. P., Severina, I. S., Grigor'ev, N. B., Granik, V. G. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Jan2004, Vol. 38 Issue 1, p15-18, 4p |
| Abstrakt: |
The article investigates the NO-donor activity of the anti microbila drug tinidazole. Tinidazole is a drug used in antiprotozoal chemotherapy. Since tinidazole is close to metronidazole, in both chemical structure and the spectrum of chemotherapeutic activity, it is suggested that these drugs have like mechanisms of action and possess analogous NO donor properties. The appearance of NO in a system in the presence of a superoxide anion leads to the formation of a cytotoxic agent, peroxynitrite anion. The superoxide anion is formed in the course of tinidazole biotransformation. Thus, peroxynitrite anions may at least partly account for the activity of tinidazole, as well as of the entire class of nitroimidazoles. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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