| Autor: |
Loftfield, Erikka, Stepien, Magdalena, Viallon, Vivian, Trijsburg, Laura, Rothwell, Joseph A, Robinot, Nivonirina, Biessy, Carine, Bergdahl, Ingvar A, Bodén, Stina, Schulze, Matthias B, Bergman, Manuela, Weiderpass, Elisabete, Schmidt, Julie A, Zamora-Ros, Raul, Nøst, Therese H, Sandanger, Torkjel M, Sonestedt, Emily, Ohlsson, Bodil, Katzke, Verena, Kaaks, Rudolf |
| Předmět: |
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| Zdroj: |
JNCI: Journal of the National Cancer Institute; Nov2021, Vol. 113 Issue 11, p1542-1550, 9p |
| Abstrakt: |
Background: Alcohol is an established risk factor for several cancers, but modest alcohol-cancer associations may be missed because of measurement error in self-reported assessments. Biomarkers of habitual alcohol intake may provide novel insight into the relationship between alcohol and cancer risk.Methods: Untargeted metabolomics was used to identify metabolites correlated with self-reported habitual alcohol intake in a discovery dataset from the European Prospective Investigation into Cancer and Nutrition (EPIC; n = 454). Statistically significant correlations were tested in independent datasets of controls from case-control studies nested within EPIC (n = 280) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC; n = 438) study. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations of alcohol-associated metabolites and self-reported alcohol intake with risk of pancreatic cancer, hepatocellular carcinoma (HCC), liver cancer, and liver disease mortality in the contributing studies.Results: Two metabolites displayed a dose-response association with self-reported alcohol intake: 2-hydroxy-3-methylbutyric acid and an unidentified compound. A 1-SD (log2) increase in levels of 2-hydroxy-3-methylbutyric acid was associated with risk of HCC (OR = 2.54, 95% CI = 1.51 to 4.27) and pancreatic cancer (OR = 1.43, 95% CI = 1.03 to 1.99) in EPIC and liver cancer (OR = 2.00, 95% CI = 1.44 to 2.77) and liver disease mortality (OR = 2.16, 95% CI = 1.63 to 2.86) in ATBC. Conversely, a 1-SD (log2) increase in questionnaire-derived alcohol intake was not associated with HCC or pancreatic cancer in EPIC or liver cancer in ATBC but was associated with liver disease mortality (OR = 2.19, 95% CI = 1.60 to 2.98) in ATBC.Conclusions: 2-hydroxy-3-methylbutyric acid is a candidate biomarker of habitual alcohol intake that may advance the study of alcohol and cancer risk in population-based studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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