| Autor: |
Lee, In-Song, Chang, Jun-Ho, Kim, Dae-Won, Kim, Seong-Gon, Kim, Tae-Woo |
| Předmět: |
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| Zdroj: |
Maxillofacial Plastic & Reconstructive Surgery; 11/1/2021, Vol. 43 Issue 1, p1-6, 6p |
| Abstrakt: |
Background: 4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol. Method: In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1–100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied. Results: In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1–100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h). Conclusion: 4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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