| Autor: |
Ravi, Nuchu, Venkatanarayana, Muvvala, Sharathbabu, Haridasyam, Babu, Kilaru Ravendra |
| Předmět: |
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| Zdroj: |
Phosphorus, Sulfur & Silicon & the Related Elements; 2021, Vol. 196 Issue 11, p1018-1024, 7p |
| Abstrakt: |
A series of novel α-aminophosphonates of diethyl (2,4-difluorobenzylamino)methylphosphonate derivatives (4a–4g) have been synthesized by applying three-component Kabachnik–Fields reaction, using fluoro derivatives of aldehydes and substituted amines, diethyl phosphonate in the presence of a catalytic amount of methanesulfonic acid (MSA) in good yields with high enantioselectivities (up to 98% ee). The enantioselectivitiy of compounds (4a–4g) was confirmed by chiral HPLC. The direct Kabachnik–Fields reaction with high reactivity under mild reaction conditions and significantly used for synthesis of the α-aminophosphonate. The novel products were characterized by spectral and analytical data. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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