| Autor: |
Saeedi, Mina, Raeisi-Nafchi, Maryam, Sobhani, Sepideh, Mirfazli, Seyedeh Sara, Zardkanlou, Mahsa, Mojtabavi, Somayeh, Faramarzi, Mohammad Ali, Akbarzadeh, Tahmineh |
| Zdroj: |
Molecular Diversity; Nov2021, Vol. 25 Issue 4, p2399-2409, 11p |
| Abstrakt: |
In this work, various imidazo[1,2-a]pyridines linked to carbamate moiety were designed, synthesized, and evaluated for their α-glucosidase inhibitory activity. Among synthesized compounds, 4-(3-(tert-Butylamino)imidazo[1,2-a]pyridin-2-yl)phenyl p-tolylcarbamate (6d) was the most potent compound (IC50 = 75.6 µM) compared with acarbose as the reference drug (IC50 = 750.0 µM). Kinetic study of compound 6d indicated a competitive inhibition. Also, the molecular docking study suggested desired interactions with the active site residues. In particular, hydrogen bonds and electrostatic interactions constructed by compound 6d afforded well-oriented conformation in the 3A4A active site. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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