Gold Glyconanoparticles Based on Aldoses 6-Mercaptohexanoyl Hydrazones and Their Anti-Influenza Activity.

Autor:	Ershov, А. Yu., Martynenkov, А. А., Lagoda, I. V., Kopanitsa, M. A., Zarubaev, V. V., Slita, A. V., Buchkov, E. V., Panarin, E. F., Yakimansky, А. V.
Předmět:	ALDOSES HYDRAZONES INFLUENZA GOLD nanoparticles NATURAL products
Zdroj:	Russian Journal of General Chemistry; Sep2021, Vol. 91 Issue 9, p1735-1739, 5p
Abstrakt:	A method for the synthesis of mixed-ligand gold glyconanoparticles with average particle size of 20–25 nm at widely variable ratio of the initial glycoligands on the basis of aldoses 6-mercaptohexanoyl hydrazones—condensation products of a series of natural aldoses (N-acetylamino-D-glucose, D-mannose, D-galactose, and L-fucose) with 6-mercaptohexanoic acid hydrazide—has been developed. It has been shown that the obtained gold glyconanoparticles exhibit low toxicity and are active against influenza A/Puerto Rico/8/34 (H1N1) virus at concentrations of 3 and 6 μg/mL. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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