Psychostimulant treatment of adults with mental retardation and attention-deficit hyperactivity disorder.

Autor:	Jou, Roger, Handen, Benjamin, Hardan, Antonio
Předmět:	PSYCHOSES STIMULANTS INTELLECTUAL disabilities BEHAVIOR disorders in children ADULT-child relationships PLACEBOS METHYLPHENIDATE AMPHETAMINES AFFECT (Psychology) COMBINATION drug therapy ATTENTION-deficit hyperactivity disorder CLINICAL trials DRUG administration DOSE-effect relationship in pharmacology PEOPLE with intellectual disabilities MOTOR ability PERSONALITY assessment QUALITY of life SOCIAL skills TREATMENT effectiveness CENTRAL nervous system stimulants DIAGNOSIS THERAPEUTICS PSYCHOLOGY
Zdroj:	Australasian Psychiatry; Dec2004, Vol. 12 Issue 4, p376-379, 4p
Abstrakt:	Objective: To examine the potential effectiveness and tolerability of psychostimulants in adults with mental retardation (MR) and attention-deficit hyperactivity disorder (ADHD).Methods: A retrospective chart review was conducted in a clinic specialized in treating individuals with developmental disabilities. Improvement was assessed using the Aberrant Behaviour Checklist-Community Version (ABC-C) and the global improvement item of the Clinical Global Impression scale.Results: Ten consecutive adult outpatients were identified. Five were judged to be responders, based on impressions from chart review and the ABC-C. Significant improvements were observed in the hyperactivity and irritability subscales of the ABC-C. Adverse events were minimal and no patients required treatment termination.Conclusions: Psychostimulants might be effective and well-tolerated in the treatment of ADHD in adults with MR. However, larger prospective open-label studies, and, eventually, double-blind placebo-controlled studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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