| Autor: |
Quendt, Corinna, Ochs, Jasmin, Häusser‐Kinzel, Silke, Häusler, Darius, Weber, Martin S., Häusser-Kinzel, Silke |
| Předmět: |
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| Zdroj: |
Annals of Neurology; Nov2021, Vol. 90 Issue 5, p834-839, 6p |
| Abstrakt: |
The frequency of CD20+ T cells was reported to be increased in several inflammatory conditions. We report that in patients with multiple sclerosis (MS), CD20+ T cells display a distinct proinflammatory phenotype with pathogenic properties. Anti-CD20 treatment virtually extinguished CD20+ T cells, which might explain its broad effectiveness. Dimethyl fumarate dampened activity of differentiated CD20+ T cells, whereas fingolimod reduced their abundance only as part of its overall T cell suppressive capacity. Natalizumab increased the frequency of CD20+ effector T cells. Widely used MS therapeutics affect this proinflammatory T cell subset with assumed pathogenic potential in a surprisingly differential manner. ANN NEUROL 2021 ANN NEUROL 2021;90:834-839. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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