The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes.

Autor:	Rathkolb, Birgit, Decker, Tanja, Fuchs, Edith, Soewarto, Dian, Fella, Christiane, Heffner, Stephan, Pargent, Walter, Wanke, Rüdiger, Balling, Rudi, Hrabé#de Angelis, Martin, Kolb, Helmut J., Wolf, Eckhard
Předmět:	BLOOD pigments HEMOPROTEINS GENOMES RADIOGENETICS GENETIC mutation HUMAN gene mapping
Zdroj:	Mammalian Genome; Jul2000, Vol. 11 Issue 7, p543-546, 04p
Abstrakt:	This article focuses on ENU mouse mutgenesis. The Munich ENU Mouse Mutagenesis Project within the German Human Genome Project is a phenotype-driven approach to produce, identify, and characterize new mouse mutants. The focus of the clinical-chemical screen is on laboratory diagnostic procedures (mainly blood-based) suitable to detect hematological changes, defects of various organ systems, and changes in metabolic pathways and electrolyte homeostasis. Mice with decreased hemoglobin concentration are defined as anemic. The type of anemia is specified by the mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC).
Databáze:	Complementary Index
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