Autor: |
El Farrash, Rania Ali, Shinkar, Dina Mohammed, Diaa El Dine Salem, Dalia Ahmed, Said El Azazy, Reem Khalid |
Předmět: |
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Zdroj: |
QJM: An International Journal of Medicine; 2021 Supplement, Vol. 114, pi303-i303, 1/3p |
Abstrakt: |
Background: Neonatal jaundice is one of the most common problems that affect newborn infants, and phototherapy is usually used for treatment. Phototherapy is generally considered a very safe and well-tolerated treatment for hyperbilirubinaemia. However, clinical users should be aware of the unwanted effects of using phototherapy. Affection of neonatal immune system due to phototherapy has been reported. Objectives: Evaluation of the effect of phototherapy on neonatal immune system through measuring the level of CD4þ lymphocytes. Methods: A prospective cohort study was conducted on full term newborns assigned to three groups: group1 neonates with hyperbilirubinemia treated by conventional phototherapy, group2 neonates treated by LED phototherapy and healthy neonates as control group. The percentages and absolute counts ofCD4þ lymphocytes were measured by flow cytometry before phototherapy and 48h after exposure. Results: The study showed a significant decrease in CD4þ percentage in patients after 48h of exposure to conventional phototherapy (P value < 0.05). There was a significant decrease in CD4þ absolute counts after 48h of exposure to both types of phototherapy. Conclusion: Conventional and LED phototherapy which is used in the treatment of neonatal hyperbilirubinemia, caused a decrease in CD4þ absolute count 48 hours after phototherapy. Also conventional phototherapy caused a decrease in CD4þ% 48 hours after exposure. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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