| Autor: |
Youssef, Tarek M., Yousry, Wael A., Salama, Mohamed M., Ahmed, Ahmed E., Awaad, Islam A. |
| Předmět: |
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| Zdroj: |
QJM: An International Journal of Medicine; 2021 Supplement, Vol. 114, pi185-i185, 1p |
| Abstrakt: |
Background: Differentiating between functional bowel disorders and organic colonic disorders can often be difficult as they may be present with similar symptoms. Aim of the Work: to evaluate the diagnostic value of plasma M2-pyruvate kinase level in differentiating functional colonic disorders (e.g: IBS) from organic colonic disorders (e.g: IBD, colorectal polyps and colorectal cancer) and to assess its use as screening tools for inflammatory bowel disease, premalignant and malignant colorectal lesions. Patients and Methods: This study was conducted on 80 patients who divided into four groups: Group I: included 20 patients, representing functional bowel disorders (as a control group). Group II: included 20 patients with inflammatory bowel diseases; Group III: included 20 patients with colorectal polyps; Group IV: included 20 patients with colorectal cancer. Results: The current study showed that plasma M2 - PK can be used to differentiate functional from organic colonic lesions at a cut-off point > 3 U/mL, with 93.33% sensitivity, 100% specificity, 100% PPV and 83.3% NPV. Also, plasma M2-PK can be used to discriminate between benign (colorectal polyp) and malignant colonic lesions (CRC) with a cut-off level of > 12 U/ml, with 100% sensitivity, 100% specificity, 100% PPV and 100% NPV. Also, In the present study there was a highly significant + ve correlations between Plasma M2 PK level and CEA as (r - 0.787, p value = 0.000) and their combination can give higher sensitivity and specificity. Conclusion: Plasma M2-PK can differentiate between functional and organic colonic disorders as it is more elevated in organic than functional colonic disorders. Also, it is considered a promising rapid noninvasive biomarker for organic colonic disorders early detection and screening to reduce unnecessary endoscopic intervention. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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