| Autor: |
Shaheen, Karim Yehia, Al Ahmed, Hala Abdel, Ali Shaaban, Menat Allah, Emam, Yasmeen Mohamed |
| Předmět: |
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| Zdroj: |
QJM: An International Journal of Medicine; 2021 Supplement, Vol. 114, pi87-i88, 2p |
| Abstrakt: |
Background: Breast cancer is a major health concern worldwide being the most frequently diagnosed cancer and a leading cause of cancer related death in females. It is a complex heterogeneous multifactorial disease where recently; genetic factors have emerged as major factors in the pathogenesis of the disease. Aim of the Work: The aim of the present study is to investigate the association of TCF7L2 rs12255372 (G/T) gene polymorphism with breast cancer and the clinicopathological characteristics of the patients. Subjects and Methods: It is a case control study conducted at Ain Shams University Hospitals, it includes 40 breast cancer female patients and 10 age matched healthy females. Results: There was no statistically significant difference between the breast cancer patient group and the healthy female controls regarding TCF7L2 rs12255372 genotypes GG, GT and TT (p-value >0.05 respectively). Moreover, no statistically significant difference was observed between both groups as regards G and T allele frequencies (p-value > 0.05 respectively). Finally, no statistically significant difference association was recorded between the different genotypes of TCF7L2 gene and the clinicopathological characteristics of breast cancer patients (p-value > 0.05 respectively). Conclusion: the present study demonstrated the absence of a significant association of TCF7L2 SNP rs12255372 (G/T) with breast cancer or with the clinicopathological characteristics of the tumor among the studied population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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