| Autor: |
Yamaguchi, Tetsuo, Ko, Su-Joung, Jung, Jin-Song, Kim, Hyoung-Jun, Oh, Jae-Min |
| Předmět: |
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| Zdroj: |
Dalton Transactions: An International Journal of Inorganic Chemistry; 10/28/2021, Vol. 50 Issue 40, p14216-14222, 7p |
| Abstrakt: |
Matching of charge periodicity between a guest and a host enabled effective immobilization of highly water-soluble antibiotic drug, gentamicin C, in a bentonite clay by cation exchange. X-ray diffraction, infrared spectroscopy and CHNS analysis revealed the immobilization manner of gentamicin C, which was immobilized between bentonite layers via periodic charge–charge interaction with tilted arrangement, as a trication. Both gentamicin alone and a gentamicin/bentonite hybrid were coated onto a polyurethane substrate using water-borne polyurethane binder. The antibiotic character of both films was investigated as prepared or after immersion in phosphate-buffered saline till 5 days against E. coli and B. subtilis bacteria. It was clearly shown that the gentamicin/bentonite hybrid–coated film showed sustained antibacterial efficacy even after exposure to phosphate-buffered saline, while gentamicin only–coated film gradually lost its performance under the same condition. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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