Extended virulence genotypes and phylogenetic background of Escherichia coli isolates from patients with cystitis, pyelonephritis, or prostatitis.
| Autor: | Johnson, James R., Kuskowski, Michael A., Gajewski, Abby, Soto, Sara, Horcajada, Juan Pablo, de Anta, M. Teresa Jimenez, Vila, Jordi, Jimenez de Anta, M Teresa |
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| Předmět: |
ESCHERICHIA coli
PYELONEPHRITIS PROSTATITIS PROSTATE diseases CYSTITIS SIDEROPHORES MICROBIAL metabolites DRUG receptors URINE microbiology PHENOL analysis TOXIN analysis BACTERIAL antigens CELL receptors CELLS COMPARATIVE studies ESCHERICHIA coli diseases GENOMES RESEARCH methodology MEDICAL cooperation MEMBRANE proteins PROTEINS PROTEOLYTIC enzymes RESEARCH THIAZOLES TOXINS EVALUATION research |
| Zdroj: | Journal of Infectious Diseases; 1/1/2005, Vol. 191 Issue 1, p46-50, 5p |
| Abstrakt: | Molecular analysis of 63 Escherichia coli urine isolates showed that pyelonephritis (n=23) and prostatitis (n=17) isolates exhibited more virulence factors (VFs) among the 35 sought than did cystitis isolates (n=23). Several nontraditional VFs--including bmaE (M fimbriae), gafD (G fimbriae), fyuA (yersiniabactin receptor), ireA and iroN (novel siderophore receptors), cvaC (colicin [microcin] V), traT (serum-resistance associated), ibeA (invasion of brain endothelium), ompT (outer membrane protease T), and malX (pathogenicity island marker)--either differentiated significantly between syndromes (despite small numbers of isolates and possible multiple-comparison artifacts) or were broadly prevalent. Thus, interventions that target conserved uro-VFs may be possible, despite the likely existence of syndrome-specific pathogenetic mechanisms and/or host defense systems. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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