| Abstrakt: |
Background: Disopyramide Phosphate, an anti-arrhythmic drug, and has oral bioavailability of 80% with a 6-8 hour biological half-life. Presently, on the lookout, various extended-release formulations of Disopyramide phosphate are available. Objectives: In the current research, we specifically recommended the use of natural polymer to design the extended-release formulation, which improves the biocompatible property of the dosage form as compared with the conventional release dosage form. chitosan is picked as a copolymer to obtain promising sustained release action alongside mucoadhesive action. Methods: Sustained release beads of Disopyramide phosphate were prepared by ionotropic gelation technique involve; within the sight of counterions, polyelectrolytes can cross-link and structure a coat on the drug core to form hydro gels with sustain release action. In current work, microbeads are formulated utilizing various extents of sodium alginate with or without chitosan and evaluated for, FTIR, DSC, Visual Appearance, SEM, Particle size, Percentage Yield of microbeads, Drug Entrapment Efficiency, Swelling Index, In-Vitro Dissolution Studies, Release kinetic study and Stability study. Result: The formulated Disopyramide phosphate loaded microbeads show maximum drug Entrapment Efficiency, Swelling Index, In-Vitro Dissolution Studies, Release kinetic study, and Stability study. The formulation S2 was oppressed for data modeling of zero-order, Higuchi, and Korsmeyer Peppas equation, studies showed that all formulations followed zero order r2 value 0.984, Higuchi r2 0.916, and Peppas n value 0.892. The release data from all the formulation was found to fit zero-order models. The S2 formulation demonstrated high drug entrapment efficiency and a possible sustained release profile from microbeads. Conclusion: From the experimental findings it tends to be gathered that the formulated Disopyramide phosphate microbeads show the stable sustain release action. [ABSTRACT FROM AUTHOR] |
