| Autor: |
Al-Tememe, E. H., Malk, Fatima H., Hraishawi, Rawaa M. O. |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2021, Vol. 2404 Issue 1, p1-10, 10p |
| Abstrakt: |
Treatment of drug delivery system using polymeric materials is a new field of research due to their low toxic nature. In this study we prepared a Chitosan / Polyvinyl alcohol that are blended of both Zinc oxide nanoparticles (CH / PVA / ZnO) and Folic Acid drug (CH / PVA / ZnO – FA) may be use as a component of drug delivery system. These components were characterized by Scanning Electron Microscopy / Energy Dispersive X-ray spectroscopy (SEM / EDX) techniques and Zeta potential value (ZP). The results of SEM /EDX indicated that ZnO nanoparticles and Folic acid drug encapsulated into CH / PVA polymer matrix, hence can significantly improve the compactness of the polymers and these components have fair zeta potential values are (-15.3mv and -13.6mv) respectively, (ZP) was identified that CH / PVA / ZnO nanoparticles and CH / PVA / ZnO – FA formulation have a good stability. In Vitro release profile of folic acid drug also studied and shows that comulative % of drug release is (95%). In Vivo toxicity of this component were studied too and shows no toxicity of (CH / PVA / ZnO – FA) sample. These results indicated improved bioavilability and increase ability of targeting cancer tumor were successfully. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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