Manual Acupuncture Plus Usual Care Versus Usual Care Alone in the Treatment of Endometriosis-Related Chronic Pelvic Pain: A Randomized Controlled Feasibility Study.
Autor: | Armour, Mike, Cave, Adele E., Schabrun, Siobhan M., Steiner, Genevieve Z., Zhu, Xiaoshu, Song, Jing, Abbott, Jason, Smith, Caroline A. |
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Předmět: |
CHRONIC pain treatment
PELVIC pain treatment ENDOMETRIOSIS INTERLEUKINS PILOT projects PAIN measurement ELECTROENCEPHALOGRAPHY ACUPUNCTURE SELF-evaluation TREATMENT effectiveness RANDOMIZED controlled trials QUALITY of life QUESTIONNAIRES ACUPUNCTURE points DESCRIPTIVE statistics RESEARCH funding STATISTICAL sampling LONGITUDINAL method DISEASE complications EVALUATION |
Zdroj: | Journal of Alternative & Complementary Medicine; Oct2021, Vol. 27 Issue 10, p841-849, 9p |
Abstrakt: | Objective: To determine the acceptability and feasibility of acupuncture for the treatment of endometriosis-related chronic pelvic pain. Design: A prospective, randomized controlled feasibility study. Setting: Outpatient setting in Sydney, Australia. Subjects: Participants who were aged 18–45 years, had a confirmed laparoscopic diagnosis of endometriosis in the past 5 years, and had regular menstrual periods and mean pelvic pain scores ≥4/10. Interventions: Sixteen acupuncture treatments delivered by registered acupuncturists using a standardized point protocol over 8 weeks, twice per week plus usual care compared with usual care alone. Outcome measures: Primary outcome measures were feasibility, safety, and acceptability of the acupuncture intervention. Secondary outcomes were changes in self-reported pelvic pain scores, changes in quality of life as measured by the Endometriosis Health Profile (EHP-30), changes in descending pain modulation, and changes in systemic inflammation (plasma interleukin [IL-6] concentrations). Results: Twenty-nine participants were eligible to participate, with 19 participants completing the trial. There was unequal withdrawals between groups; the acupuncture group had a withdrawal rate of 14% compared with 53% in usual care. Adverse events were uncommon (6.7%) and generally mild. A 1.9 point decrease in median nonmenstrual pain scores and a 2.0 decrease in median menstrual pain scores between baseline and end of trial were observed in the acupuncture group only. Improvements in all domains of the EHP-30 were seen in the acupuncture group, with no changes seen in usual care. There was no difference between baseline and end of treatment in IL-6 concentrations for either group. Conclusions: Acupuncture was an acceptable, well-tolerated treatment and it may reduce pelvic pain and improve quality of life; however, usual care was not an acceptable control group. Trial Registration: anzctr.org.au: ACTRN12617000053325. Prospectively registered January 11, 2017. [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
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