| Autor: |
von Allmen, Douglas, Tang, Alice, Takiar, Vinita, Zender, Chad, Romeo, Stephen, Masch, Jessica, Casper, Keith, Patil, Yash, Wilson, Keith, Khosla, Siddarth, Niu, Liang, Altaye, Mekibib, Tabangin, Meredith, Howell, Rebecca J. |
| Zdroj: |
Laryngoscope; Nov2021, Vol. 131 Issue 11, p2478-2482, 5p |
| Abstrakt: |
Objectives/hypothesis: Dysphagia is a treatment-related complication of head and neck cancer (HNCA). We demonstrate the predictive value of a modified head and neck swallow scale (m-HNSW) adapted from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck 35 (EORTC-QLQ-H&N35).Study Design: Retrospective Cohort Study.Methods: Retrospective, single-center cohort study utilizing a prospectively collected database of HNCA patients in a high-volume tertiary referral center. 736 HNCA patients more than 2 years from completion of treatment were identified. EORTC-QLQ-H&N35 data collected from at least one of three defined episodes of care were used. The m-HNSW uses three questions to form a 9-point dysphagia scale. A Cox proportional hazards model was used to determine the effect of the m-HNSW while controlling for demographics, tumor staging, site, and treatment.Results: Using data from 3, 6, 12 months from treatment, we analyzed a subset that included 328 patients. Three months after the completion of therapy, the m-HNSW score had a significant association with 1 (HR = 1.24, P = .0005) and 5 year survival (HR = 1.19, P = .0002) after accounting for body mass index. Six (HR = 1.14, P = .014) and 12 month (hazard ratio (HR) = 1.33, P < .0001) scores post completion of therapy predict 5-year survival. An increase of the m-HNSW score by 1 point was associated with an increase in death by 24%, and 19% at 1 and 5 years following therapy.Conclusions: The m-HNSW is a simple assessment of dysphagia using previously validated EORTC-QLC-H&N35 data that when taken at 3, 6, and 12 months after completion of therapy is predictive of overall survival.Level Of Evidence: 4 Laryngoscope, 131:2478-2482, 2021. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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