Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019.

Autor: Martinot, Martin, Jary, Aude, Fafi-Kremer, Samira, Leducq, Valentin, Delagreverie, Heloise, Garnier, Marc, Pacanowski, Jérôme, Mékinian, Arsène, Pirenne, France, Tiberghien, Pierre, Calvez, Vincent, Humbrecht, Catherine, Marcelin, Anne-Geneviève, Lacombe, Karine
Předmět:
Zdroj: Clinical Infectious Diseases; 10/1/2021, Vol. 73 Issue 7, pe1762-e1765, 4p
Abstrakt: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered virus for which remdesivir is the only antiviral available. We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. A cure was achieved after supplementation with convalescent plasma. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index