| Autor: |
Lestari, A. D. N., Siswanta, D., Martien, R., Mudasir, M. |
| Předmět: |
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| Zdroj: |
Rasayan Journal of Chemistry; Jul-Sep2021, Vol. 14 Issue 3, p1729-1735, 7p |
| Abstrakt: |
The efficacy of the drug encapsulated in the polymeric matrix is closely related to the kinetics of drug release from the matrix, therefore the study about the kinetic release of a drug from a certain matrix is essential to be carried out. This study aims to evaluate the release of β-carotene from the starch-chitosan crosslinked by tripolyphosphate matrices (starch-chitosan/TPP) in the in vitro digestive media (artificial intestinal fluid (AIF) and artificial gastric fluid (AGF)) as well as in ethanol, and to evaluate the antioxidant activity of the released β-carotene. The effect of starch types, i.e. native and acid hydrolyzed starch, on both parameters was investigated. The results show that the β-carotene release in AIF is slower than that in AGF. In each applied medium, the release rate of β-carotene from hydrolyzed starch-chitosan/TPP matrices is slower than from native starch-chitosan/TPP matrices. The release kinetics of β-carotene in absolute ethanol medium follows the Korsmeyer-Peppas model with an exponent of release (n) value for encapsulation products using the native starch-chitosan/TPP matrix and using the hydrolyzed starch-chitosan/TPP matrix are 0.14 and 0.16, respectively. This value indicates that the mechanism of β-carotene release in both matrices follows the quasi-fickian diffusion. Furthermore, the antioxidant activity of β-carotene released from the matrices does not decrease significantly after encapsulation, indicating the effectiveness of the matrices in protecting the activity β-carotene. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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