| Autor: |
Miyauchi, Shunsuke, Tokuyama, Takehito, Shintani, Tomoaki, Uotani, Yukimi, Miyamoto, Shogo, Ikeuchi, Yoshihiro, Okamura, Sho, Okubo, Yousaku, Miyauchi, Mutsumi, Nakano, Yukiko |
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| Zdroj: |
Heart & Vessels; Nov2021, Vol. 36 Issue 11, p1721-1729, 9p |
| Abstrakt: |
Atrial fibrillation (AF) is associated with a fivefold risk of stroke and thrombotic embolism, which are usually derived from the left atrial appendage (LAA). Spontaneous echo contrast (SEC) is known as a risk factor for thrombosis. Porphyromonas gingivalis (P.gingivalis) has some prothrombotic effects and plays a key role in periodontitis and oral-systemic disease connection. We aimed to clarify the relationship between P. gingivalis and LAA SEC among AF patients. A total of 569 AF ablation candidates were enrolled in the present study. LAA SEC was categorized into nondense SEC and dense SEC based on transesophageal echocardiography. Serum immunoglobulin G antibody titers of P. gingivalis fimA subtypes (types I–IV) were measured with an enzyme-linked immunosorbent assay. The levels of antibody titers were categorized into high (> mean + 3 standard deviation) and low values. A total of 513 (90%) patients were included in the nondense SEC group, and 56 (10%) were included in the dense SEC group. Multivariate regression analysis revealed that the high-value serum antibody titers of P. gingivalis types II and IV were independently associated with dense SEC [type II: adjusted odds ratio (OR) 2.220; 95% confidence interval (CI) 1.062–4.643; P = 0.02; and type IV: adjusted OR 3.169; 95% CI 1.058–6.657; P = 0.002]. The results revealed that P. gingivalis types II and IV are related to LAA SEC severity among AF patients who receive appropriate anticoagulation therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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