| Autor: |
Lago, Tainã, Carvalho, Lucas P, Nascimento, Mauricio, Guimarães, Luiz H, Lago, Jamile, Castellucci, Léa, Carvalho, Augusto M, Lago, Alex, Carvalho, Edgar M |
| Předmět: |
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| Zdroj: |
Clinical Infectious Diseases; 9/15/2021, Vol. 73 Issue 6, p1020-1026, 7p |
| Abstrakt: |
Background Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a single ulcer or multiple cutaneous lesions with raised borders. Cure rates <60% are observed in response to meglumine antimoniate therapy. We investigated the impact of obesity on CL clinical presentation and therapeutic response. Methods A total of 90 age-matched patients with CL were included (30 obese, 30 overweight, and 30 with normal body mass index [BMI]). CL was diagnosed through documentation of L. braziliensis DNA by polymerase chain reaction or identification of amastigotes in biopsied skin-lesion samples. Serum cytokine levels were determined by chemiluminescence. Antimony therapy with Glucantime (Sanofi-Aventis; 20 mg/kg/day) was administered for 20 days. Results Obese CL patients may present hypertrophic ulcers rather than typical oval, ulcerated lesions. A direct correlation between BMI and healing time was noted. After 1 course of antimony, cure was achieved in 73% of patients with normal BMI, 37% of overweight subjects, yet just 18% of obese CL patients (P <.01). Obese CL cases additionally presented higher leptin levels than overweight patients or those with normal BMI (P <.05). Conclusions Obesity modifies the clinical presentation of CL and host immune response and is associated with greater failure to therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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