Metal‐Free One‐Pot Synthesis of 2‐(2‐Hydrazinyl) Thiazole Derivatives Using Graphene Oxide in a Green Solvent and Molecular Docking Studies.

Autor:	Das, Arindam, Dey, Sovan, Chakraborty, Sumit, Barman, Anup, Naresh Yadav, Ram, Gazi, Rabiul, Jana, Madhurima, Firoj Hossain, Md.
Předmět:	MOLECULAR docking THIAZOLE derivatives GRAPHENE oxide SOLVENTS THIOSEMICARBAZONES CARBONYL compounds GLUCOSAMINE
Zdroj:	ChemistrySelect; 9/27/2021, Vol. 6 Issue 36, p9552-9558, 7p
Abstrakt:	An efficient, one‐pot three‐component reaction in the synthesis of a wide range of 2,4‐disubstituted hydrazinyl thiazole scaffolds in ethanol at room temperature has been developed by the reaction of carbonyl compounds, phenacyl bromides, and thiosemicarbazide, using graphene oxide (GO) as a catalyst. The present catalytic method has many significant advantages such as shorter reaction time, broad substrate scope, low catalyst loading, environmentally benign solvent media, easy handling, and operational simplicity at room temperature. The products are identified based on their various spectroscopic data. The GO catalyst has a high reusability rate and is simple to recover. A mechanistic study suggests that the reaction takes place via a thiosemicarbazone intermediate, which is isolated and confirmed in this study using spectroscopic techniques. Thereafter, a molecular docking study has been performed to evaluate the binding affinity of hydrazinyl thiazole derivative as a possible inhibitor on the protein active site of human α‐amylase and glucosamine 6‐phosphate synthase [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.