| Autor: |
Franz, Laura, Kazmaier, Uli, Truman, Andrew W., Koehnke, Jesko |
| Předmět: |
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| Zdroj: |
Natural Product Reports; Sep2021, Vol. 38 Issue 9, p1659-1683, 25p |
| Abstrakt: |
Covering: 1950s up to the end of 2020 Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a D -amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009–2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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