| Autor: |
Kondo, Kyoko, Ohfuji, Satoko, Watanabe, Kenji, Yamagami, Hirokazu, Fukushima, Wakaba, Ito, Kazuya, Suzuki, Yasuo, Hirota, Yoshio |
| Předmět: |
|
| Zdroj: |
International Journal of Epidemiology; 2021 Supplement, Vol. 50, p1-1, 1p |
| Abstrakt: |
Background The prevalence of Crohn's disease is increasing in Japan, but risk factors for this disease have yet to be characterized. A recent study using mice, indicated that Klebsiella strains in the oral cavity may be associated with inflammatory bowel disease. We investigated the association between oral hygiene and Crohn's disease onset. Methods We conducted a multicenter case-control study and compared oral hygiene in 69 patients with newly diagnosed Crohn's disease to that in 113 control patients (patients with other diseases matched for institution, age, and sex). The exposure variables were number of teeth, use of dentures, implant treatment, and frequency of brushing. A conditional logistic model was used to calculate odds ratios and 95% confidence intervals of these factors for Crohn's disease onset. Results The decreased odds ratios of brushing teeth were observed with increasing daily frequency (trend for p = 0.039), with 0.52 (0.20–1.33) for twice daily brushings and 0.26 (0.07–0.97) for three or more daily brushings, (reference category: brushing no or once a day). No other oral hygiene factors were associated with the onset of Crohn's disease. Conclusions Our findings suggest that frequent brushing may have a protective association with the development of Crohn's disease. Key messages This result may provide a clue to the possible involvement of oral bacteria in the development of inflammatory bowel disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
