| Autor: |
Lisby, S., Ralfkiaer, E., Rothlein, R., Vejlsgaard, G. L. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; Apr1989, Vol. 120 Issue 4, p479-484, 6p |
| Abstrakt: |
The presence of intercellular adhesion molecule-1 (ICAM-1) on keratinocytes of psoriatic skin lesions before and during 8-methoxapsoralen and UVA light (PUVA) treatment was studied. ICAM-I was expressed on the keratinocytes in biopsies of the skin lesions of five patients with psoriasis. The patients who responded to PUVA treatment had a concurrent reduction of ICAM-I expression on the keratinocytes with a reduction of the number of cells in the mononuclear cellular infiltrate and a lessening of the severity of the disease. Patients who went into remission during therapy and then relapsed showed an increase in ICAM-1 expression on keratinocytes with an increase in the number of cells in the mononuclear cell infiltrate and an increase in the severity of the disease. HLA-DR expression on keratinocytes was variable during treatment and showed no strong correlation with disease severity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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