| Autor: |
Eberle, Alex N., Mild, Gabriele, Froidevaux, Sylvie |
| Předmět: |
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| Zdroj: |
Journal of Receptors & Signal Transduction; Nov2004, Vol. 24 Issue 4, p319-455, 137p |
| Abstrakt: |
Radiolabeled peptides have become important tools in nuclear oncology, both as diagnostics and more recently also as therapeutics. They represent a distinct sector of the molecular targeting approach, which in many areas of therapy will implement the old "magic bullet" concept by specifically directing the therapeutic agent to the site of action. In this three-part review, we present a comprehensive overview of the literature on receptor-mediated tumor targeting with the different radiopeptides currently studied. Part I summarizes the general concepts and methods of targeting, the selection of radioisotopes, chelators, and the criteria of peptide ligand development. Then, the >400 studies on the application to s omato statin/somatostatin-release inhibiting factor receptor-mediated tumor localization and treatment will be reviewed, demonstrating that peptide radio- pharmaceuticals have gained an important position in clinical medicine. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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