Adjuvant Activity of Ambient Particulate Matter in Macrophage Activity-Suppressed, N-Acetylcysteine-Treated, iNOS- and IL-4-Deficient Mice.

Autor:	Steerenberg, P. A., Withagen, C. E. T., Dalen, W. J., Dormans, J. A. M. A., Loveren, H.
Předmět:	IMMUNOLOGICAL adjuvants INTERLEUKIN-4 IMMUNOREGULATION IMMUNOMODULATORS MEDICAL research
Zdroj:	Inhalation Toxicology; Dec2004, Vol. 16 Issue 13, p835-843, 9p
Abstrakt:	In previous studies, we have shown strong adjuvant activity for Ottawa dust (EHC-93) after coexposure of the BALB/cmouse to EHC-93 and ovalbumin. Mice were intranasally sensitized at days 0 and 14 with 200μg ovalbumin and 150μg EHC-93, and challenged with ovalbumin at days 35, 38, and 41 with 200μg ovalbumin. Mice were autopsied at day 42. This adjuvant activity was shown for the antibody response to ovalbumin (immunoglobulins E, G1, and G2a), histopathological lesions in the lung, cytokines, and the numbers of eosinophils in lung lavages. To study the mechanisms of this adjuvant activity, mice (BALB/cC.D2-Vil6) with natural-resistance-associated macrophage protein (Nramp1s), BALB/cmice pretreated with the antioxidantN-acetylcysteine (NAC), mice (B6.129P2-Nos2tmLau) deficient in inducible nitric oxide synthase (iNOS), and mice with interleukin-4 (IL-4) deficiency (BALB/cIl4
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.