| Autor: |
Taljaard, J. J. F., Shanley, B. C., Stewart-Wynne, E. G., Deppe, W. M., Joubert, S. M. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; Sep1972, Vol. 87 Issue 3, p261-269, 9p |
| Abstrakt: |
Eight patients with symptomatic porphyria↑ (porphyria cutanea tarda symptomatica, PCT) were treated with small doses of chloroquin sulphate over periods ranging from 2 to 16 weeks. A good clinical and biochemical response was obtained in all but one patient, who relapsed after initial improvement. Manifestations of acute untoward reaction were seen in one patient only. It is concluded that low dose chloroquine therapy is both safe and effective in PCT. Studies in porphyric rats indicate that the mechanism of action of chloroquine in PCT is probably not related, as has been suggested, to the formation of a chloroquine-porphyrin complex which damages liver cells and thereby leads to a reduction in hepatic porphyrin stores. Chloroquine therapy led to increased urinary iron excretion and an increase in the desferrioxamine-chelatable iron in patients with PCT. It is suggested that the prolonged beneficial effects of chloroquine treatment may be related to reduction in a specific pool of liver iron. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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