| Autor: |
Dousset, L., Martins, C., Jacquemin, C., Amico, S., Schatton, T., Boniface, K., Seneschal, J. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; Sep2021, Vol. 185 Issue 3, p663-666, 4p |
| Abstrakt: |
Dear Editor, The use of immune checkpoint inhibitors (ICIs), such as anti-programmed cell death-1 (PD-1) antibodies, has profoundly changed melanoma prognosis. Immunofluorescence analysis of a pretreatment skin biopsy showed CD8 SP + sp T cells at the invasive tumour margin, with only a subset of cells expressing the T SB RM sb antigen CD103 (Figure 1b). Complete response in a patient with advanced melanoma following anti-PD-1 therapy is associated with a high frequency of melanoma-infiltrating CXCR3+ resident memory CD8+ T cells and multiple chemokine pathways. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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